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Scientific Poster Download
World ADC London 2023
WuXiDAR4: A simple but powerful approach to produce homogeneous ADC products
Qing Zhou, Xudong Dai, Yun He, Jin Jin, Jun Wang, Li Yin, Jincai Li
Biologics Conjugation Development, WuXi XDC
| Historically, conjugation of chemical payloads to mAbs (mainly IgG1 & IgG4) by reducing Cysteine inter-chain disulfide bonds dominated the conjugation strategy in the generation of ADCs. However this traditional mechanism was problematic as it typically resulted in significant amounts of heterogeneous products with a wide DAR distribution. Here we introduce the novel and proprietary WuXiDAR4 technology platform for producing ADCs more efficiently and with higher DAR4 population. |  |
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