Custom Protein Generation

Drug Substance Manufacturing

Drug Product Fill & Finish

Development

Testing

Discovery

Antibody Drug Conjugates

Technologies & Platforms

Development of functional or potency assays is one of the most challenging aspects of biotherapeutic development.  Knowing this, WuXi Biologics has dedicated a team of over 70 experienced scientists to the development, optimization and validation of cell-based bioassays.  This team has developed over 115 cell-based assays including over 25 qualified for GMP release testing for our clients worldwide.

MAb Functional Assays

Below are several bioassays developed specifically for monoclonal antibodies. Contact us to see the full list of bioassays developed by our expert team or to see how we can support your potency assay development.

Fab functional characterization
  • Antigen-binding assay (ELISA, SPR)
  • Cell binding assay (FACS, ECL)
  • Proliferation assay
  • Cellular apoptosis/cytotoxicity assay
  • Cytokine release assay
  • Neutralization assay
  • Endocytosis and internalization assay
  • Phagocytosis assay
  • Luciferase reporter gene assay
  • Adhesion and migration assay
  • Antigen-specific immune response and its regulation

Fc functional characterization
  • FcγR binding assay (ELISA, SPR)
  • FcRn binding assay (ELISA, SPR)
  • CDC & ADCC

BACK