Anti-human serum albumin (HSA) VHH discovery, a building block for PK prolongation
Yunying Chen, Xin Lin, Yi Qin, Donghui Wu, Jijie Gu
WuXi Biologics, 1951 West Huifeng Road, Fengxian District, Shanghai, China
Single domain antibody (VHH) molecules (around 15 kD), derived from camelid heavy-chain-only IgG, are attracting increased attention globally in the field of antibody-based therapies due to several features including small size, high stability, low immunogenicity, good tissue penetration and cost effectiveness in manufacturing. In this poster, we summarize the discovery of an anti-human/cyno/mouse serum albumin VHH lead from a proprietary high-quality large alpaca/llama native phage-displayed library, humanized and optimized the lead molecule with improved affinity.
This scientific poster was originally presented during the Chinese Antibody Society 2023 conference