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Mass Spectrometry Characterization

The Center of Excellence for Mass Spectrometry provides technical support for sophisticated development, manufacturing and investigation efforts, including protein structure analysis, in-depth protein structure characterization, protein glycoform analysis, and host-cell protein analysis. The center hosts 8 world-class mass spectrometers and more than 30 mass spectrometry specialists, and has accomplished the characterization analysis of over 100 protein molecules of a variety of modalities, including monoclonal antibodies, bi-specific antibodies and fusion proteins. 

 

The center offers comprehensive characterization strategies for clients, 

and is well-equipped to service mass-spectrometry-based independent projects.


  • Sequence coverage by LC-MS/MS
  • N- and C-terminal sequence by LC-MS/MS
  • Post-translational Modification by LC-MS/MS
  • Disulfide linkage analysis by LC-MS
  • Intact/deglycosylated intact mass analysis by LC-MS
  • Reduced/deglycosylated reduced mass analysis by LC-MS
  • Middle level Ides digestion mass analysis by LC-MS
  • CE-MS with 908 Device
  • Quick N-Glycan analysis by LC-MS
  • N-glycosylation ID and analysis by FLD and HILIC-MS
  • N and O-glycosylation ID and analysis by glycopeptides using LC-MS/MS
  • N- or O-glycosylation sites by LC-MS/MS
  • Qualitative ID HCP proteins by LC-MS/MS
  • Quantitative measurement of HCP proteins by LC-MS/MS
  • Sequence variants analysis by LC-MS/MS
  • Impurity characterization (peak fractionation and characterization)
  • MSn technique to identify mutation and rare PTMs

Equipments