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Webinar

Achieving High Titer & Superior Purity Across Diverse Bispecific Antibody Formats
Oct. 31, 2024
Achieving High Titer & Superior Purity Across Diverse Bispecific Antibody Formats

Webinar title:

 Achieving High Titer & Superior Purity Across Diverse Bispecific Antibody Formats

 

Abstract:

Bispecific antibodies (BsAbs) are at the forefront of therapeutic innovation, but their production is often hindered by challenges such as low titers and difficult-to-remove impurities like homodimers and mispaired species. Additionally, each BsAb format presents unique complexities in the production process.

 

This webinar will showcase innovative solutions to these challenges, including ultra-high-titer CHO expression systems, optimized chain ratios, and Intact Mass-assisted purification processes tailored for various formats like CrossMab, WuXiBody, and others. Through detailed case studies, we will demonstrate how these approaches consistently achieve over 98% heterodimer purity and endotoxin levels below 0.1 EU/mg.

 

In this webinar, you will learn:

 

  • Innovative strategies to overcome low titers, mispaired species and homodimers.
  • Advanced chain ratio optimization for formats like CrossMab and WuXiBody, improving expression and titer.
  • Case studies illustrating Intact Mass-assisted purification tailored for various formats, such as CrossMab, WuXiBody, and ScFv-Fab, consistently achieving heterodimer purity >98% and endotoxin levels <0.1 EU/mg.

 

Speakers:

Jiansheng Wu, Ph.D., Vice President, Head of CRO Services

View This Recording and other Protein Science Webinars