Webinar

In Vitro Assays for T Cell Engagers and Autoimmune Targets – From Bench to Data-Driven Decisions

June 3, 2025

In Vitro Assays for T Cell Engagers and Autoimmune Targets – From Bench to Data-Driven Decisions

Webinar title:

In Vitro Assays for T Cell Engagers and Autoimmune Targets – From Bench to Data-Driven Decisions

Abstract:

Standard bioassays often fall short when evaluating immune-modulating biologics due to their diverse mechanisms of actions (MOAs) and functional complexity. To generate meaningful preclinical data, context-specific in vitro models are essential.

In this webinar, we will explore the strategic application of tailored bioassays for two key therapeutic areas: T cell engagers (TCEs) in oncology and biologics targeting autoimmune pathways. Through real-world case studies, we will demonstrate how rational assay design, such as T cell activation, redirected killing, cytokine release, and target-specific inhibition, can support robust assessment of drug potency, specificity, and MOAs.

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In this webinar, you will learn:

Proven strategies for assay design, optimization, and biological interpretation in preclinical development
How in vitro models, from bispecific format evaluation to cytokine signaling inhibition in PBMCs, can bridge discovery and translational relevance
Practical approaches for transforming complex bioassay data into actionable insights to guide drug development

Speakers:

Rachel Wang, Ph.D.

Associate Director (SME), CRO Services

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