E. coli expression systems play a significant role in biologics development, especially for producing proteins where post-translational modifications (PTMs) aren’t crucial or can be addressed later in the process. Their speed, cost-effectiveness, and ability to yield large quantities make them invaluable tools in bioprocessing, particularly for research, early-stage development, and certain biologics manufacturing.
At WuXi Biologics, our Protein Sciences (PS) Department has extensive experience in E. coli recombinant protein production. We excel in scaling up E. coli fermentation, demonstrating expertise in producing both soluble proteins and refolding inclusion bodies. This enables us to consistently deliver high-quality recombinant proteins at scales ranging from small to large, catering to various research stages.