T cell receptor (TCR) therapy, a novel approach for targeting intracellular proteins via major histocompatibility complex (MHC), is gaining traction in the drug development field. Traditionally, E. coli was used for TCR expression, but encountered challenges such as low yield and limited throughput.
To overcome these challenges, we have developed the T Cell Mate service. Utilizing our high-titer CHO expression system, this service enables the high-throughput production of soluble TCRs, TCR fusion proteins and single-chain trimers (SCT) with high yield. Additionally, the T Cell Mate service offers refolded peptide-MHC complexes (RF-pMHC) production in E. coli.