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State-of-the-Art Equipment and Methods

High-throughput and Automation Instrumentation supporting Formulation and Process Development

  • MFI – sub visible particles
  • HIAC – sub visible particles
  • Flex-P – automated visible particle imaging system
  • FTIR microscope – particle identification
  • DLS – nano scale size distribution
  • DLS plate reader – high throughput testing of size, Tagg and Kd
  • Freeze-drying microscope – Tc for lyophilization cycle development 
  • mDSC – Tg’
  • PEAQ DSC & VP DSC – conformational stability evaluation
  • cIEF – charge heterogeneity testing
  • Material tester – break-loose force, gliding force, cap removal force
  • Rheometer – viscosity and rheology
  • Uncle – all-in-one stability screening
  • Force tensiometer – surface tension related measurement
  • Microfluidic modulation spectroscopy – secondary structure analysis
  • Image Dimension Measurement System – for PFS
  • Densitometer – density measurement
  • HPLC / UPLC – SEC, CEX, RP analysis 
  • High throughput work station for buffer exchange
  • Automated sample preparation and testing system
  • High throughput protein quantification system – testing of concentration and turbidity
  • CG-MALS – mechanism of aggregation and nucleation 
  • Freeze / thaw system – freeze & thaw process development and stability studies using a minimal amount of product
  • Microfluidizer – nanocrystalline / nanoparticle / nanoemulsion formation
  • Headspace analyzer – container and closure integrity testing
  • Silicone oil distribution analyzer – for PFS
  • Microfluidizer Processor – for nanoparticle
  • Nano Liposome Extruder – for nanoparticle
  • Low Field Nuclear Magnetic Resonance – moisture content and protein concentration

mDSC

DLS plate reader

Rheometer

Freeze-drying microscope

DSC

Automated screening station

High throughput buffer exchange

CG-MALS

Filling line

Lyophilizer

Freeze-thaw System

MFI

Headspace analyzer

Silicone oil distribution analyzer

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