Centers Of Excellence

Mass Spectrometry Characterization

The Center of Excellence for Mass Spectrometry provides technical support for sophisticated development, manufacturing and investigation efforts, including protein structure analysis, in-depth protein structure characterization, protein glycoform analysis, and host-cell protein analysis. The center hosts 8 world-class mass spectrometers and more than 30 mass spectrometry specialists, and has accomplished the characterization analysis of over 100 protein molecules of a variety of modalities, including monoclonal antibodies, bi-specific antibodies and fusion proteins.

The center offers comprehensive characterization strategies for clients,

and is well-equipped to service mass-spectrometry-based independent projects.

Primary Structure
Glycosylation/Carbohydrate
HCP Analysis by LC-MS/MS
Detailed Characterization

Sequence coverage by LC-MS/MS
N- and C-terminal sequence by LC-MS/MS
Post-translational Modification by LC-MS/MS
Disulfide linkage analysis by LC-MS
Intact/deglycosylated intact mass analysis by LC-MS
Reduced/deglycosylated reduced mass analysis by LC-MS
Middle level Ides digestion mass analysis by LC-MS
CE-MS with 908 Device

Quick N-Glycan analysis by LC-MS
N-glycosylation ID and analysis by FLD and HILIC-MS
N and O-glycosylation ID and analysis by glycopeptides using LC-MS/MS
N- or O-glycosylation sites by LC-MS/MS

Qualitative ID HCP proteins by LC-MS/MS
Quantitative measurement of HCP proteins by LC-MS/MS

Sequence variants analysis by LC-MS/MS
Impurity characterization (peak fractionation and characterization)
MSn technique to identify mutation and rare PTMs

Mass Spectrometry Characterization

Equipments