WuXi Biologics’ manufacturing platform WuXiUI™ introduces an ultra-intensified fed-batch strategy for highly improved upstream productivity and cost-effective commercial manufacturing. It leverages an innovative cell culture bioprocess with ultra-high seeding density and intermittent-perfusion fed-batch to achieve 3 to 6-fold higher productivity than traditional fed-batch processes while maintaining desirable product quality. The platform’s unique design allows for outstanding adaptability for all common cell lines and diverse modalities, and is readily scalable to 2000 L – 12,000 L scales with high productivity and 60-80% reduced manufacturing cost of goods (COGs).
The industries most common mammalian expression systems (e.g., CHO-K1, CHO-S, CHO-M, CHO-GS etc.) used in modern bioprocessing are compatible with the WuXiUI platform to produce a wide array of biotherapeutic modalities including monoclonal, bispecific and multispecific antibodies, Fc fusion proteins and enzymes. Similar to perfusion cell culture, WuXiUI is an ideal solution for difficult to express recombinant proteins.
For more information on how the WuXiUI platform can dramatically improve cell culture productivity and drive down your biologics manufacturing cost of goods see this webinar or – contact us.