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Scientific Poster Download

Poster modified on 14/10/2024

Break Loose Force and Glide Force Evaluation of Various Container Closure System Combinations
Jeremy Guo, Tao Yali, Zhou Yuan, Zhao Zhixin, Chen Quanmin
Drug Product Development, WuXi Biologics

A comprehensive evaluation of break loose force and glide force (BLGF) was conducted on 1 ml long (L) and 2.25 ml empty prefillable syringes (PFS) from three vendors, paired with four to five types of plunger stoppers. Twelve container closure system (CCS) combinations for 1 mL L syringes and fifteen for 2.25 mL syringes were assessed. The study found that plunger stopper properties, particularly design and formulation, significantly influence BLGF performance, while variations in silicone oil levels do not. Download our poster to explore these insights further.

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