WuXi Biologics
Offering End-to-End Solutions
Monoclonal Antibody Discovery
More than 100 monoclonal antibodies (mAbs) have been approved in clinics for treatment of cancer, autoimmune disorders, and inflammatory and infectious diseases. MAbs are also important building blocks for the design and construction of bispecific, multispecific and biparatopic antibodies, antibody drug conjugates (ADC) and CAR (chimeric antigen receptor) T-cell therapeutics. WuXi Biologics has extensive experience in the generation and lead preclinical candidate (PCC) discovery of mAbs from human, mouse, rat, alpaca, llama and rabbit covering traditional and heavy-chain-only mAbs. WuXi Biologics has established multiple core technology platforms including hybridoma, phage display, yeast display and single B cell screening approaches for mAb discovery.
Hybridoma
WuXi Biologics provides antibody generation through traditional hybridoma approaches using our WuXiHybrid™ advanced hybridoma-monoclonal antibody technology platform. We also offer multiple approaches for generating fully human antibodies using transgenic animals from either Ligand’s OmniAb® or Alloy Therapeutics’ ATX-Gx™ platforms. WuXi Biologics has successfully delivered 200+ therapeutic antibody discovery projects via our hybridoma platform. In addition, our team of experts have extensive experience with GPCR (G Protein-Coupled Receptor) & other difficult targets.
Key Features:
Phage Display
WuXi Biologics offers high-quality phage display library construction and customized library selection and screening services via our WuXiLiAb® human naive/synthetic phage display libraries, VHH naive libraries and antibody immune libraries. In addition, we have extensive experience for challenging targets such as GPCR (G-Protein Coupled Receptor), ion-channel, multi-subunit complex.
Process and Timeline:
WuXi Biologics has constructed human naïve libraries from 50+ donors with more than 1*1011 transformants representing nearly all of the human antibody V-gene repertoire. WuXi Biologics has also designed and constructed human synthetic libraries based on dominant germline pair of heavy and light chains with more than 1*1012 transformants. WuXi Biologics has successfully delivered 40+ antibody discovery projects based on human naive/synthetic display platform. Typical project timelines include:
Key Features:
VHH Generation
WuXi Biologics offers high-quality alpaca immune library construction and customized library selection and screening services. WuXi Biologics has constructed alpaca naïve libraries from 100+ alpaca donors with more than 3*10^11 transformants. We have successfully delivered 70+ VHH antibody discovery projects based on immunization and naive phage display libraries. Typical project timelines include:
Key Features:
Single B Cell Screening
WuXi Biologics utilizes the Berkeley Lights Beacon Optofluidic® systems’ highly efficient single B cell screening methodology to identify lead monoclonal antibodies and to dramatically reduce the traditional discovery timelines.
Key Features of Single B Screen on the Beacon® Optofluidic system:
Typical Single B cell Screening Timeline
Single B Cell Screening Process
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