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Other Molecular Modalities
WuXi Biologics offers extensive design, generation, and discovery of new molecular modalities, including but not limited to: bispecific / multispecific antibodies, ADCs, recombinant proteins, fusion proteins, cytokines, immunocytokines, peptides, nanobodies, antibody fragments, TCR-based antibodies, viral proteins, and other biologics. Our team of experts work with you to establish the best path in optimizing your molecule to its target and for its intended purpose.
Antibody Drug Conjugates (ADCs)
WuXi Biologics offers comprehensive, one-stop in vitro and in vivo characterization services to assist our clients and enable them to discover the ideal ADC candidate to move into CMC development and on to clinical trials.
ADC In Vitro Characterization Platform
Comprehensive biologics screening and characterization throughout the lead drug candidate selection process is provided. We also offer assay development services as required for your specific project needs. ADC in vitro characterization services and methods include:
Antigen-antibody binding methods
- ELISA
- FACS
- SPR
Internalization analysis
- pHrodo
- Acid quench
- Co-localization
- Time-course
Other critical in vitro characterization evaluations
- High-throughput and quick cytotoxicity assessment
- Bystander killing
- Free-payload release and drug-to-antibody ratio (DAR) stability for serum or plasma samples
For more information including case studies illustrating our in vitro characterization capabilities for ADCs, download this informative flyer: https://www.wuxibiologics.com/adc-characterization-services-info/
ADC In Vivo Characterization Platform
Our highly-trained scientists and experts provide the full-spectrum of in vivo characterization services including in vivo efficacy evaluation of therapeutic antibodies, ADCs and other large molecules for the treatment of tumors, autoimmune conditions, inflammatory disease, diabetes and other diseases. Capabilities include:
- Variety of in vivo efficacy evaluation models using an extensive array of tumor/mouse models
- Full methodologies for PK profiling validated for consistency and accuracy to detect total antibody, total ADC and free drug using advanced methodologies:
- LC-MS
- ELISA
- MSD: Fc-Fc, Fc-Fab, Fc-Drug
- High-quality PD evaluation utilizing FACS, ELISA, MSD and IVIS systems.
- Comprehensive, high-capacity histological evaluations using state-of-the-art instrumentation
For more case studies illustrating our in vivo characterization capabilities for ADCs, download this informative flyer: https://www.wuxibiologics.com/adc-characterization-services-info/
WuXi Biologics provides an extensive variety of tumor/mouse models for in vivo efficacy characterization of ADCs.
Learn more about our capabilities for ADC’s:
- WuXi XDC, part of WuXi Biologics, is specialized in ADC and bioconjugation discovery and development: https://www.wuxibiologics.com/wuxi-xdc/conjugation-rd/
- Numerous ADC-related publications are available: https://www.wuxibiologics.com/publications/
- Bioconjugation services for custom diagnostic and imaging reagents as well as “ready-made” GMP-grade chemical payloads/linkers: https://www.wuxibiologics.com/payloads-and-linkers/
Fusion Protein
Our Fusion Protein Services include the following. For additional services please Contact Us.
- Protein generation services
- Expression level
- Stability
- Binding
- Function
- Half-life
- Discovery project
Cytokine/Immunocytokine
Cytokine/Immunocytokine services are available. For additional services please Contact Us.
- Protein generation services
- Expression level
- Stability
- Binding
- Function
- Half-life
- Discovery project
Other Protein Design and Engineering Services Available. For additional services please Contact Us.
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Engineered proteins
- Virus proteins
- TCR based therapeutics
- Peptides
- Linkers
- Platform development
- Design to meet intended purpose
- Expression level
- Stability
- Binding
- Function
- Half-life
- Discovery project
