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Ready-Made
Payloads and Linkers

Ready-Made Chemical Payloads & Linkers

 

WuXi XDC offers a growing library of common payloads and linkers for use in a variety of R&D and pharmaceutical purposes including use as chemical intermediates in the production of antibody drug conjugates (ADCs) and other bioconjugates. These ready-made or “ready-to-conjugate” small molecule entities are available as either GMP- and non-GMP grade. 

 

Payloads and Linkers 

 

Below is short list of common payloads and linkers available for immediate purchase (GMP or non-GMP). For the full list of “ready-to-conjugate” chemical entities see the table at the bottom of this webpage.

 

Payload

 

  • Payloads: MMAE*, VC-MMAE*, MMAF, MC-MMAF*, DM1, DM4, SN38, Exatecan mesylate (DX-895 1f)*, PNU159682, PBD, and Teserine.

 

Linker

 

  • Linkers: MC-VC-PAB-PNP, Glu-VC-PAB, NHS-Glu-VC- PAB, Azido-Glu-VC-PAB, Hydrazone (acid sensitive), Disulfide (glutathione sensitive), SMCC and Fmoc-VAL- ALA-PAB-PNP

 

*Drug Master File (DMF) is available with specific regulatory agencies. Please contact us (see submission form on the right) for more information.


Customized Payload & Linker Services

 

As a one-stop CRDMO (Contract Research, Development and Manufacturing Organization), we also offer customized payload, linker and payload-linker discovery, development and manufacturing services utilizing hundreds of dedicated and highly trained scientists and engineers.

 

Our specialized small molecule R&D and manufacturing teams have deep experience in the identification, optimization and commercialization of NCEs (new chemical entities) or existing chemical payloads and linkers and have extensive know-how for the design of proprietary synthetic routes. Our enabling technologies and capabilities include:

 

  • Hydrogenation
  • Flow chemistry
  • Bio-catalysis
  • Chemo-catalysis

 

With OEB 5 protection within our laboratories and GMP manufacturing suites, efficient project management systems, expertise for right-first-time execution and uncompromised quality, WuXi XDC has an extensive history of providing on-time delivery of customized molecules for your various R&D and GMP manufacturing needs.

 

 Click here to learn more


 

The following tables provide a list of ready-made payloads and linkers available for immediate
purchase. As our library of compounds in inventory is continuously growing, please contact
us to inquire if we have the chemical entity you require. For more information or to receive a
quotation complete and submit the form provided above on this webpage.

 

Payloads

Chemical Name (Short Form / Acronym)

CAS* Number

Chemical Name (Full)

Chemical Formula

Molecular Weight

DMF Available?

MMAE

474645-27-7

Monomethyl auristatin E / Dolastatin-10

C39H67N5O7

717.99

Yes

MMAF

745017-94-1

Monomethylauristatin F

C38H63N5O8

717.95

Yes

DM1

139504-50-0

Mertansine (a maytansoid derivative)

C35H48CIN3O10S

738.29

Under Draft

DM4

796073-69-3

N2’-deacetyl-N2’-(4-mercapto-4-methyl-1- oxopentyl) maytansine

C38H54CIN3O10S

780.37

No

SN-38

119577-28-5

12-Ethyl-9-hydroxycamptothecin (7-ethyl-10-hydroxycamptothecin

C22H20N2O5

392.41

No

DX-8951f

169869-90-3

Exatecan mesylate

C25H26FN3O7S

531.50

Yes

PNU-159682

202350-68-3

Metabolite of the anthracycline nemorubicin

C32H35NO13

641.63

No

PBD (SGD-1882)

1222490-34-7

Pyrrolobenzodiazepine

C42H39N5O7

725.80

No

DXD

1599440-33-1

Exatecan derivative

C26H24FN3O6

493.49

No

Camp 98

N/A

Camptothecin derivative

C25H25FN2O5

452.48

No

 

Linkers

Chemical Name (Short Form / Acronym)

CAS* Number

Chemical Name (Full)

Chemical Formula

Molecular Weight

DMF Available?

MC-VC-PAB-PNP

1350456-64-2

Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate

C35H43N7O11

737.77

No

Glu-VC-PAB

N/A

Glutamic acid-valine-citrulline-p-aminobenzyl alcohol

C23H35N5O7

493.56

No

NHS-Glu-VC- PAB

N/A

N-hydroxysuccinimide-glutamic acid-valine-citrulline-p-aminobenzyl alcohol

C27H38N6O9

590.63

No

Azido-Glu-VC-PAB

N/A

Azido-glutamic acid-valine-citrulline-p-aminobenzyl alcohol

C22H34N8O5

490.57

No

Hydrazone

151889-43-9

Hydrazone (an acid sensitive moiety)

C12H16N2

188.27

No

SMCC

64987-85-5

Succinimidyl-4- ( N -maleimidomethyl)cyclohexane-1-carboxylate

C16H18N2O6

334.33

Yes

Fmoc-Val- Ala-PAB-PNP

1394238-92-6

Fluorenylmethyloxycarbonyl-valine-alanine-p-aminobenzyl alcohol p-nitrophenyl carbonate

C37H36N4O9

641.63

No

MC-VC-PAB-PFP

N/A

Maleimidocaproyl-L-valine-L-citrulline-p-amino benzyl alcohol pentaflurophenyl carbonate

C35H39F5N6O9

782.72

No

Fmoc-Val- Ala-PAB-PFP

N/A

Fluorenylmethyloxycarbonyl-valine-alanine-p-amino benzyl alcohol pentaflurophenyl carbonate

C37H32F5N3O7

725.67

No

Fmoc-VC-PAB

159858-22-7

Fmoc-L-valine-L-citrulline-p-amino benzyl alcohol

C33H39N5O6

601.70

No

VC-PAB

159857-79-1

L-valine-L-citrulline-p-amino benzyl alcohol

C18H29N5O4

379.46

No

 

 

Payload-Linkers

Chemical Name (Short Form / Acronym)

CAS* Number

Chemical Name (Full)

Chemical Formula

Molecular Weight

DMF Available?

vcMMAE

646502-53-6

Valine-citrulline-monomethyl auristatin E

C68H105N11O15

1316.65

Yes

mcMMAF

863971-19-1

Maleimidocaproyl monomethylauristatin F

C47H74N6O10

883.14

Yes

MC-GGFG-Dxd

N/A

N-((S)-7-benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de] pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12-tetraoxo-3-oxa-5,8,11-triazatridecan-13-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide

C50H53FN8O12

977.02

No

MC-GGFG-Exatecan

1600418-29-8

6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-(((S)-1-((2-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl) amino)-2-oxoethyl)hexanamide

C49H51FN8O11

946.99

No

HA-VC-PAB-MMAE

N/A

4-((S)-2-((S)-2-(2-(aminooxy)acetamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5R)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl) pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate

C60H97N11O14

1196.50

No

CL2A-SN38

1279680-68-0

4-(2-(4-aminobutyl)-35-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamido)methyl)-1H-1,2,3-triazol-1-yl)-4,8-dioxo-6,12,15,18,21,24,27,30,3 3-nonaoxa-3,9-diazapentatriacontanamido) benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3’,4’:6,7] indolizino[1,2-b]quinolin-4-yl) carbonate

C73H97N11O22

1480.63

No

DM1-SMCC

1228105-51-8

2,5-dioxopyrrolidin-1-yl (1S,4r)-4-((3-((3-(((S)-1-(((14S,16S,32S,33S,2R,4S,10E,12E,1-4R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4-)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl) oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-carboxylate

C51H66CIN5O16S

1072.62

No

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