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Ready-Made
Payloads and Linkers
Ready-Made Chemical Payloads & Linkers
WuXi XDC offers a growing library of common payloads and linkers for use in a variety of R&D and pharmaceutical purposes including use as chemical intermediates in the production of antibody drug conjugates (ADCs) and other bioconjugates. These ready-made or “ready-to-conjugate” small molecule entities are available as either GMP- and non-GMP grade.
Payloads and Linkers
Below is short list of common payloads and linkers available for immediate purchase (GMP or non-GMP). For the full list of “ready-to-conjugate” chemical entities see the table at the bottom of this webpage.
- Payloads: MMAE*, VC-MMAE*, MMAF, MC-MMAF*, DM1, DM4, SN38, Exatecan mesylate (DX-895 1f)*, PNU159682, PBD, and Teserine.
- Linkers: MC-VC-PAB-PNP, Glu-VC-PAB, NHS-Glu-VC- PAB, Azido-Glu-VC-PAB, Hydrazone (acid sensitive), Disulfide (glutathione sensitive), SMCC and Fmoc-VAL- ALA-PAB-PNP
*Drug Master File (DMF) is available with specific regulatory agencies. Please contact us (see submission form on the right) for more information.
Customized Payload & Linker Services
As a one-stop CRDMO (Contract Research, Development and Manufacturing Organization), we also offer customized payload, linker and payload-linker discovery, development and manufacturing services utilizing hundreds of dedicated and highly trained scientists and engineers.
Our specialized small molecule R&D and manufacturing teams have deep experience in the identification, optimization and commercialization of NCEs (new chemical entities) or existing chemical payloads and linkers and have extensive know-how for the design of proprietary synthetic routes. Our enabling technologies and capabilities include:
- Hydrogenation
- Flow chemistry
- Bio-catalysis
- Chemo-catalysis
With OEB 5 protection within our laboratories and GMP manufacturing suites, efficient project management systems, expertise for right-first-time execution and uncompromised quality, WuXi XDC has an extensive history of providing on-time delivery of customized molecules for your various R&D and GMP manufacturing needs.
The following tables provide a list of ready-made payloads and linkers available for immediate purchase. Details for each molecule including chemical structure, can be seen clicking on the CAS number link. As our library of compounds in inventory is continuously growing, please contact us to inquire if we have the chemical entity you require. For more information or to receive a quotation complete and submit the form provided on this webpage.
Payloads
|
Chemical Name (Short Form / Acronym) |
CAS* Number |
Chemical Name (Full) |
Chemical Formula |
Molecular Weight |
DMF Available? |
|
MMAE |
Monomethyl auristatin E / Dolastatin-10 |
C39H67N5O7 |
717.99 |
Yes |
|
|
MMAF |
Monomethylauristatin F |
C38H63N5O8 |
717.95 |
Yes |
|
|
DM1 |
Mertansine (a maytansoid derivative) |
C35H48CIN3O10S |
738.29 |
Under Draft |
|
|
DM4 |
N2’-deacetyl-N2’-(4-mercapto-4-methyl-1- oxopentyl) maytansine |
C38H54CIN3O10S |
780.37 |
No |
|
|
SN-38 |
12-Ethyl-9-hydroxycamptothecin (7-ethyl-10-hydroxycamptothecin |
C22H20N2O5 |
392.41 |
No |
|
|
DX-8951f |
Exatecan mesylate |
C25H26FN3O7S |
531.50 |
Yes |
|
|
PNU-159682 |
Metabolite of the anthracycline nemorubicin |
C32H35NO13 |
641.63 |
No |
|
|
PBD (SGD-1882) |
Pyrrolobenzodiazepine |
C42H39N5O7 |
725.80 |
No |
|
|
DXD |
Exatecan derivative |
C26H24FN3O6 |
493.49 |
No |
|
|
Camp 98 |
Camptothecin derivative |
C25H25FN2O5 |
452.48 |
No |
Linkers
|
Chemical Name (Short Form / Acronym) |
CAS* Number |
Chemical Name (Full) |
Chemical Formula |
Molecular Weight |
DMF Available? |
|
MC-VC-PAB-PNP |
Maleimidocaproyl-L-valine-L-citrulline-p-aminobenzyl alcohol p-nitrophenyl carbonate |
C35H43N7O11 |
737.77 |
No |
|
|
Glu-VC-PAB |
Glutamic acid-valine-citrulline-p-aminobenzyl alcohol |
C23H35N5O7 |
493.56 |
No |
|
|
NHS-Glu-VC- PAB |
N-hydroxysuccinimide-glutamic acid-valine-citrulline-p-aminobenzyl alcohol |
C27H38N6O9 |
590.63 |
No |
|
|
Azido-Glu-VC-PAB |
Azido-glutamic acid-valine-citrulline-p-aminobenzyl alcohol |
C22H34N8O5 |
490.57 |
No |
|
|
Hydrazone |
Hydrazone (an acid sensitive moiety) |
C12H16N2 |
188.27 |
No |
|
|
SMCC |
Succinimidyl-4- ( N -maleimidomethyl)cyclohexane-1-carboxylate |
C16H18N2O6 |
334.33 |
Yes |
|
|
Fmoc-Val- Ala-PAB-PNP |
Fluorenylmethyloxycarbonyl-valine-alanine-p-aminobenzyl alcohol p-nitrophenyl carbonate |
C37H36N4O9 |
641.63 |
No |
|
|
MC-VC-PAB-PFP |
Maleimidocaproyl-L-valine-L-citrulline-p-amino benzyl alcohol pentaflurophenyl carbonate |
C35H39F5N6O9 |
782.72 |
No |
|
|
Fmoc-Val- Ala-PAB-PFP |
Fluorenylmethyloxycarbonyl-valine-alanine-p-amino benzyl alcohol pentaflurophenyl carbonate |
C37H32F5N3O7 |
725.67 |
No |
|
|
Fmoc-VC-PAB |
Fmoc-L-valine-L-citrulline-p-amino benzyl alcohol |
C33H39N5O6 |
601.70 |
No |
|
|
VC-PAB |
L-valine-L-citrulline-p-amino benzyl alcohol |
C18H29N5O4 |
379.46 |
No |
Payload-Linkers
|
Chemical Name (Short Form / Acronym) |
CAS* Number |
Chemical Name (Full) |
Chemical Formula |
Molecular Weight |
DMF Available? |
|
vcMMAE |
Valine-citrulline-monomethyl auristatin E |
C68H105N11O15 |
1316.65 |
Yes |
|
|
mcMMAF |
Maleimidocaproyl monomethylauristatin F |
C47H74N6O10 |
883.14 |
Yes |
|
|
MC-GGFG-Dxd |
N-((S)-7-benzyl-1-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de] pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl)amino)-1,6,9,12-tetraoxo-3-oxa-5,8,11-triazatridecan-13-yl)-6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)hexanamide |
C50H53FN8O12 |
977.02 |
No |
|
|
MC-GGFG-Exatecan |
6-(2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)-N-(2-((2-(((S)-1-((2-(((1S,9S)-9-ethyl-5-fluoro-9-hydroxy-4-methyl-10,13-dioxo-2,3,9,10,13,15-hexahydro-1H,12H-benzo[de]pyrano[3’,4’:6,7]indolizino[1,2-b]quinolin-1-yl)amino)-2-oxoethyl)amino)-1-oxo-3-phenylpropan-2-yl)amino)-2-oxoethyl) amino)-2-oxoethyl)hexanamide |
C49H51FN8O11 |
946.99 |
No |
|
|
HA-VC-PAB-MMAE |
4-((S)-2-((S)-2-(2-(aminooxy)acetamido)-3-methylbutanamido)-5-ureidopentanamido)benzyl ((S)-1-(((S)-1-(((3R,4S,5R)-1-((S)-2-((1R,2R)-3-(((1S,2R)-1-hydroxy-1-phenylpropan-2-yl)amino)-1-methoxy-2-methyl-3-oxopropyl) pyrrolidin-1-yl)-3-methoxy-5-methyl-1-oxoheptan-4-yl)(methyl)amino)-3-methyl-1-oxobutan-2-yl)amino)-3-methyl-1-oxobutan-2-yl)(methyl)carbamate |
C60H97N11O14 |
1196.50 |
No |
|
|
CL2A-SN38 |
4-(2-(4-aminobutyl)-35-(4-((4-((2,5-dioxo-2,5-dihydro-1H-pyrrol-1-yl)methyl)cyclohexane-1-carboxamido)methyl)-1H-1,2,3-triazol-1-yl)-4,8-dioxo-6,12,15,18,21,24,27,30,3 3-nonaoxa-3,9-diazapentatriacontanamido) benzyl ((S)-4,11-diethyl-9-hydroxy-3,14-dioxo-3,4,12,14-tetrahydro-1H-pyrano[3’,4’:6,7] indolizino[1,2-b]quinolin-4-yl) carbonate |
C73H97N11O22 |
1480.63 |
No |
|
|
DM1-SMCC |
2,5-dioxopyrrolidin-1-yl (1S,4r)-4-((3-((3-(((S)-1-(((14S,16S,32S,33S,2R,4S,10E,12E,1-4R)-86-chloro-14-hydroxy-85,14-dimethoxy-33,2,7,10-tetramethyl-12,6-dioxo-7-aza-1(6,4-)-oxazinana-3(2,3)-oxirana-8(1,3)-benzenacyclotetradecaphane-10,12-dien-4-yl) oxy)-1-oxopropan-2-yl)(methyl)amino)-3-oxopropyl)thio)-2,5-dioxopyrrolidin-1-yl)methyl)cyclohexane-1-carboxylate |
C51H66CIN5O16S |
1072.62 |
No |
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