Establishment of an Ultra High-Throughput Protein Production Platform (Ultra 96) for Early Stage in vitro Studies
Kai Jiang, Huishuai Li, Mengjie Lu, Chuanlong Tang, Xuejian Zhang, Ying Zhang, Zhengyang Zhao, Jun Zhou, Jiansheng Wu
WuXi Biologics, NO.240 Hedan Road, Pudong New District, Shanghai, China
In early stage drug discovery, numerous μg to mg scale high quality proteins need to be produced for in vitro functional studies and therapeutic evaluation, including antigens, monoclonal antibodies (mAb), bispecific antibodies (bsAbs) as well as other Fc-fusion proteins. Here we present how WuXi Biologics has created a powerful ultra HTP protein production platform (termed as “Ultra 96”) that can automatically produce proteins within 3 weeks with one step purification at 1~ 3mL expression scale by using 96 and 24 well DWP.
This scientific poster was originally presented during the Festival of Biologics 2023 conference