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Quick’n Clean Services

Unlock the Optimal Pairings of Bispecific Antibodies Quickly & Cost-Effectively

 

Bispecific antibody production entails challenges like heterogeneity, production complexity, and stability issues, impacting the quality of the final product. With the use of our Quick’n Clean platform, our experts are able to apply innovative strategies to address these challenges, whether you need small-scale high-throughput screening of large quantities of BsAb pairings or large-scale production.

 

Our platform can produce 1 mg of customized BsAb with 99% heterodimer in 3-4 weeks starting from 20 mL culture medium using a 3-step automated purification process. With the capability to provide high throughput screening of large number of customized BsAb, our “Quick ’n Clean” platform is highly suitable for early-stage drug discovery.

 

 

Quick’n Clean Service Details

 

Service Item Deliverables Duration QC
Gene synthesis, cloning and plasmid prep all included.
20 mL

20 mL• Average 1 mg
• 3-step automatic purification
• 99% heterodimer

3-4 weeks <0.5 EU/mg endotoxin control, QC incl. Titer, A280, Caliper (R/NR) or SDS-PAGE, SEC-HPLC
1 L
CHO/HEK293
50 mg 3-4 weeks
Additional QC

RP-HPLC, bioburden, DSF, DSC, SPR, LC/MS, SEC-MALS, peptide mapping, glycan profiling, cIEF, CHO HCP, residual DNA, ELISA, Western blot, freeze thaw study, micro-developability testing