Telephone sharing button Contact Us linkedin sharing button Share wechat sharing button Share wechat sharing button Twitter mailbox sharing button
arrow_left sharing button
arrow_right sharing button

GMP Conjugation Manufacturing

At WuXi XDC, the conjugation manufacturing process for ADC/bioconjugate drug substance starts with payload-linker dispensing and consists of the conjugation reaction, purification and bulk filling. 


There are two dispensing cabinets for weighing and dissolving highly-potent compounds, which include a stainless steel negative pressure isolator and a single-use plastic isolator. 


See the table below for manufacturing capacities.

Lab scale
Non-GMP pilot scale
cGMP manufacturing
 > 2 kg
> 5 kg
Up to 5 kg

  • Key equipment


    • OEB5 Isolator for payload-linker dispensing and dissolution
    • Mixing tanks (10 L, 50 L, 100 L, 200 L, 500 L, and 1,000 L)
    • Single-use  glass or plastic bioreactors , (5 L, 15 L, 30 L, 50 L,  100 L, 200 L and 500 L)
    • AKTA Ready, UF/DF system

  • Bioconjugation is conducted at our Drug Product manufacturing facility (DP3) located in Wuxi, China.  For more information on the site’s capabilities and capacities – click here

  • In addition to ADC/bioconjugate drug substance and drug product GMP manufacturing, WuXi XDC’s single-source bioconjugate platform includes non-GMP and GMP manufacture of all intermediates including the mAb/protein, payload and linkers.

For more information