DNA-encoded antibody delivery
Monoclonal antibodies have been widely used in the treatment for tumor, inflammatory and autoimmune disorders. However, high costs, and dose frequency limit patients’ accessibility to these therapeutic modalities. DNA delivery presents a labor- and cost-effective alternative to antibody therapeutics, with less frequent delivery and simpler formulation. Nanoparticle delivery systems overcome the biological barriers in vivo, and prolong circulation and improve antibody expression and sustainability. Thus, DNA delivery provides a viable, long-term treatment option. At WuXi Biologics, we have an experienced team to perform in vivo and ex vivo studies to identify lead candidate in this new area for biologics.