Discovery

Development

Testing

Drug Product Fill & Finish

Antibody Drug Conjugates

Technologies & Platforms

TMT Video for Tuesday, Febuary 7, 2017

About Two Minute Tuesday (TMT) videos

The Keck Graduate Institute and WuXi Biologics have teamed together to provide technical training videos for the bioprocessing industry.  Because we know you are busy working professionals we have condensed these videos into 2-3 minute segments dedicated to a particular topic.  We will deliver via email every Tuesday another topic for you to peruse at your leisure.  Whether you are new to or have several years’ experience working in the biologics industry and regardless if you are a research scientist/engineer or C-Level executive, these short videos can quickly get you up-to-speed in understanding the complexities of biologics drug development and manufacturing. To watch more of these videos see below our Two Minute Tuesday training video archive.

Two Minute Tuesday Archive

Subscribe to our mailing list





Cell Culture Development Training Series

Bioprocessing Overview

This training video focuses on the basics of biologics development and outlines the common steps in a modern bioproduction process, particularly the cell culture (or upstream) unit operations.

Dissolved Oxygen and CO2

This training video explains in detail how different oxygen and carbon dioxide levels would affect cell growth and product quality and how we closely monitor these two parameters in bioreactors during the production process.

Sparging

This training video discusses the important considerations in the introduction of air and thus oxygen into cell culture media via sparging and talks about the common types of sparging equipment.

Mixing

This training video reviews the impact of mixing within a bioreactor during the production process, the influencing factors on the mixing results and the key measures to manage and control mixing.

Aeration Part 1

This training video is part 1 of a tutorial on the impact of aeration on cell culture production and discusses optimizing the delivery of oxygen to the cells and the rate limiting factors that can impact this critical aspect of bioproduction.

Aeration Part 2

This training video is part two of the tutorial on aeration and it looks at various factors that can impact Kla such as mixing, air flow and air-liquid interfacial surface area.

Chemically defined media

This training video focuses on the importance of culture media in the overall cell culture development process, the critical components that comprise chemically defined media and reviews the evolution of culture media over time.

pH value

This training video on pH details its importance for optimal cell growth within a bioreactor, what factors can impact pH and how to control the pH of the growth media during production.


Expert Interview with Tom Fletcher – Chemically Defined Media

An interview with Tom Fletcher, Part 1

Part 1 of an expert interview with Tom Fletcher on when, where and how to optimize media.

An interview with Tom Fletcher, Part 2

Part 2 of an expert interview with Tom Fletcher on the benefits of using chemically defined media.

An interview with Tom Fletcher, Part 3

Part 3 of an expert interview with Tom Fletcher on the impact of chemically defined media on product quality.

An interview with Tom Fletcher, Part 4

Part 4 of an expert interview with Tom Fletcher on CDM (chemically defined media) feed vs growth media and the role of hydrolysates.

Expert Interview with Robert Garrahy – Use of pH Probes in Bioprocessing

An interview with Robert Garrahy, part 1

Part 1 of an expert interview with Robert Garrahy on pH probe selection and set-up.

An interview with Robert Garrahy, part 2

Part 2 of an expert interview with Robert Garrahy on reusable and disposable pH probes.

An interview with Robert Garrahy, part 3

Part 3 of an expert interview with Robert Garrahy on pH probe calibration.

Expert Interview with Shawn Latham – Bioprocess Validation

An interview with Shawn Latham, part 1

Part 1 of an expert interview with Shawn Latham on maintaining a validated state.

An interview with Shawn Latham, part 2

Part 2 of an expert interview with Shawn Latham on the changes in bioprocess validation.

An interview with Shawn Latham, part 3

Part 3 of an expert interview with Shawn Latham on early stage validation considerations.

An interview with Shawn Latham, part 4

Part 4 of an expert interview with Shawn Latham on validation beyond the process.

BACK