CRISPR/Cas9 Gene Editing Services

CRISPR/Cas9 is a powerful, time-saving molecular biology tool for gene or genome editing that can be applied to a wide variety of applications within vaccine or biotherapeutic discovery and product development. WuXi Biologics has taken a research license of CRISPR/Cas9 technologies from the Broad Institute for use in biologics and vaccine research and development. Whether changing the glycan profiles of monoclonal antibodies or optimizing cellular protein expression in a producer cell line, the utility of CRISPR is vast and our team of experts can help you determine if the use of CRISPR is right for your product and project needs.

Applying CRISPR Technology to Enhance Your Drug Development Efforts

Applications for CRISPR gene editing that can be applied to producer cell lines or other protein expression systems to improve cell growth, productivity, product titer and product quality include but are not limited to:

Post-translational modifications(PTMs) of protein product
Metabolic engineering (e.g., knockout fucose glycosylation)
Engineering cells for hypothermic growth
Regulating apoptosis in cells
Regulating cell cycle progression
Engineering of chaperones and foldases

Our highly trained scientists can provide customized advice and services for a wide variety of gene editing functions including:

Microbial or mammalian cell genome editing services
DNA or RNA editing
Transcription activation or repression
Gene editing of mAbs, Fc-fusion proteins, enzymes, bispecific Abs, plasmids and a wide range of viral vaccine or gene therapy vectors
Inducible gene activation and inhibition with CRISPRa and CRISPRi
Reporter cells and other non-CRISPR mediated engineering available

WuXi Biologics offers Crispr/Cas9 gene editing services as a stand-alone service or as part of our comprehensive cell line development or integrated DNA to IND CMC programs.

For more information

Listen to our Podcast: Application and Impact of CRISPR/Cas9 in Bioprocessing